1435727-11-9
Chemical Structure
6β-Naltrexol-d3
Synonym(s): 6β-Hydroxynaltrexone-d3
- CAS No.: 1435727-11-9
- Formula:C20H22D3NO4
- Molecular Weight:346.44
InChIKey: JLVNEHKORQFVQJ-ZNMQZXPKSA-N
SMILES: O[C@@]12[C@@]3([C@]([H])([C@@H](CC2)O)O4)CCN([C@@H]1CC5=CC=C(O)C4=C35)C([2H])(C6(CC6)[2H])[2H]
Biological Activity: 6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1][2].
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6β-Naltrexol-d3 | 6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit. | |||||||||||||||||||||
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6β-Naltrexol | 99.03% | 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Cone EJ, et al. Biosynthesis, isolation, and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J Pharm Sci. 1975 Apr;64(4):618-21. [Content Brief]
Keywords
