1440532-30-8
Chemical Structure
TWIK-1/TREK-1-IN-1
- CAS No.: 1440532-30-8
- Formula:C21H24F3NO3
- Molecular Weight:395.42
InChIKey: KCWGFZJFASQMQC-GOSISDBHSA-N
SMILES: OC(CC1)(C2=CC=CC=C2)CCN1C[C@@H](O)COC3=CC=C(C(F)(F)F)C=C3
Biological Activity: TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1].
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TWIK-1/TREK-1-IN-1 | TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects. | |||||||||||||||||||||
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Keywords
