144734-36-1
144734-36-1
Chemical Structure
4F 4PP oxalate
- CAS No.: 144734-36-1
- Formula:C24H28FNO5
- Molecular Weight:429.48
IUPAC Name: (4-fluorophenyl)(1-(4-phenylbutyl)piperidin-4-yl)methanone oxalate
InChIKey: VUJYJCRJPFMHEM-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(F)C=C1)C2CCN(CCCCC3=CC=CC=C3)CC2.O=C(O)C(O)=O
Biological Activity: 4F 4PP (oxalate) is a selective 5-HT2A antagonist with almost as high affinity (Ki= 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki= 620 nM)[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4F 4PP oxalate | 98.86% | 4F 4PP (oxalate) is a selective 5-HT2A antagonist with almost as high affinity (Ki= 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki= 620 nM). | ||||||||||||||||||||
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References
- [1]. Aira Z, et al. Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors. Pain. 2012;153(7):1418-1425. [Content Brief]
- [2]. Lee SH, et al. Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol. 2018;142(4):1349-1352.e16. [Content Brief]
- [3]. Rodríguez-Muñoz M, et al. Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. 2018;9(34):23373-23389. Published 2018 May 4. [Content Brief]
- [4]. Gerhold KJ, et al. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 2015;35(26):9580-9594. [Content Brief]
Keywords
