1448363-50-5
Chemical Structure
Dihydroeleutherinol-8-O-β-D-glucopyranoside
- CAS No.: 1448363-50-5
- Formula:C21H24O9
- Molecular Weight:420.41
InChIKey: IRDPRBBMSJDQCP-JHGFXMOGSA-N
SMILES: OC1=CC(O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=CC3=CC(C)=C(C(C[C@@H](O4)C)=O)C4=C13
Biological Activity: Dihydroeleutherinol-8-O-β-D-glucopyranoside is an anti-inflammatory agent. Dihydroeleutherinol-8-O-β-D-glucopyranoside exists in the rhizomes of Eleutherine bulbosa and acts as a pro-inflammatory cytokine inhibitor. Dihydroeleutherinol-8-O-β-D-glucopyranoside inhibits the production of IL-12 p40 (IC50 = 1.0 μM) and IL-6 (IC50 = 5.0 μM) in lipopolysaccharide-stimulated dendritic cells. At the tested concentrations, Dihydroeleutherinol-8-O-β-D-glucopyranoside does not inhibit the production of TNF-α in lipopolysaccharide-stimulated dendritic cells and shows no cytotoxicity against dendritic cells. Dihydroeleutherinol-8-O-β-D-glucopyranoside can be used in studies related to rheumatoid arthritis[1][2].
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Dihydroeleutherinol-8-O-β-D-glucopyranoside | Dihydroeleutherinol-8-O-β-D-glucopyranoside is an anti-inflammatory agent. Dihydroeleutherinol-8-O-β-D-glucopyranoside exists in the rhizomes of Eleutherine bulbosa and acts as a pro-inflammatory cytokine inhibitor. Dihydroeleutherinol-8-O-β-D-glucopyranoside inhibits the production of IL-12 p40 (IC50 = 1.0 μM) and IL-6 (IC50 = 5.0 μM) in lipopolysaccharide-stimulated dendritic cells. At the tested concentrations, Dihydroeleutherinol-8-O-β-D-glucopyranoside does not inhibit the production of TNF-α in lipopolysaccharide-stimulated dendritic cells and shows no cytotoxicity against dendritic cells. Dihydroeleutherinol-8-O-β-D-glucopyranoside can be used in studies related to rheumatoid arthritis. | |||||||||||||||||||||
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- [1]. Ha LM, et al. Chemical Constituents of the Rhizome of Eleutherine bulbosa and Their Inhibitory Effect on the Pro-Inflammatory Cytokines Production in Lipopolysaccharide-Stimulated Bone Marrow-derived Dendritic Cells. Bulletin of the Korean Chemical Society. 2013;34(2):633-636.
- [2]. Hanh PTB, et al. Toxicity and Anti-inflammatory Activities of an Extract of the Eleutherine bulbosa Rhizome on Collagen Antibody-induced Arthritis in a Mouse Model. Natural Product Communications. 2018;13(7).
