1448757-02-5
Chemical Structure
Dyrk1A-IN-15
- CAS No.: 1448757-02-5
- Formula:C14H9NO4S
- Molecular Weight:287.29
InChIKey: GZIAWSAJVKTXCQ-UHFFFAOYSA-N
SMILES: OC1=CC(C2=NC3=CC(OCO4)=C4C=C3S2)=CC=C1O
Biological Activity: Dyrk1A-IN-15 is a selective, brain-penetrant and ATP-competitive Dyrk1A inhibitor with a IC50 of 19 nM. Dyrk1A-IN-15 displays high selectivity across a broad kinase panel (specific for DYRK kinases) with nanomolar potency. Dyrk1A-IN-15 impairs neurosphere self-renewal, cell invasion, and EGFR stability in vitro. Dyrk1A-IN-15 inhibits tumor growth and prolongs survival in vivo. Dyrk1A-IN-15 has potential for glioblastoma (GBM) research[1].
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Dyrk1A-IN-15 | Dyrk1A-IN-15 is a selective, brain-penetrant and ATP-competitive Dyrk1A inhibitor with a IC50 of 19 nM. Dyrk1A-IN-15 displays high selectivity across a broad kinase panel (specific for DYRK kinases) with nanomolar potency. Dyrk1A-IN-15 impairs neurosphere self-renewal, cell invasion, and EGFR stability in vitro. Dyrk1A-IN-15 inhibits tumor growth and prolongs survival in vivo. Dyrk1A-IN-15 has potential for glioblastoma (GBM) research. | |||||||||||||||||||||
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Keywords
