1451412-34-2
Chemical Structure
Orexin receptor antagonist 6
- CAS No.: 1451412-34-2
- Formula:C29H32F3N3O5
- Molecular Weight:559.58
InChIKey: KFNSZWWIIUHELF-UHFFFAOYSA-N
SMILES: O=C(CN1CCC2=CC(OC)=C(C=C2C1CC3=CC=C(C(OC)=C3)OC)OCC(F)(F)F)NCC4=CC=CN=C4
Biological Activity: Orexin receptor antagonist 6 (Compound 72) is a selective orexin 1 receptor (OX1) antagonist with a Ke of 8.5 nM and > 1180-fold selectivity for OX2. Orexin receptor antagonist 6 does not produce its own conditioned place preference (CPP) or aversive effects, and can inhibit the formation of CPP induced by psychoactive substances. Orexin receptor antagonist 6 can be used for research of neurological disease[1].
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Orexin receptor antagonist 6 | Orexin receptor antagonist 6 (Compound 72) is a selective orexin 1 receptor (OX1) antagonist with a Ke of 8.5 nM and > 1180-fold selectivity for OX2. Orexin receptor antagonist 6 does not produce its own conditioned place preference (CPP) or aversive effects, and can inhibit the formation of CPP induced by psychoactive substances. Orexin receptor antagonist 6 can be used for research of neurological disease. | |||||||||||||||||||||
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Keywords
