148473-36-3
Chemical Structure
JMV 390-1
- CAS No.: 148473-36-3
- Formula:C23H35N3O6
- Molecular Weight:449.54
IUPAC Name: ((R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl)-L-isoleucyl-L-leucine
InChIKey: MWZOULASPWUGJJ-NFBUACBFSA-N
SMILES: O=C(N[C@H](C(O)=O)CC(C)C)[C@H]([C@@H](C)CC)NC([C@@H](CC(NO)=O)CC1=CC=CC=C1)=O
Biological Activity: JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium[1].
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JMV 390-1 | JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium. | |||||||||||||||||||||
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Keywords
