153049-49-1
Chemical Structure
PD 145065
- CAS No.: 153049-49-1
- Formula:C52H67N7O10
- Molecular Weight:950.13
IUPAC Name: (2S,5S,8S,11S,14S,17R)-2-((1H-indol-3-yl)methyl)-5,8-di((S)-sec-butyl)-11-(carboxymethyl)-17-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-14-isobutyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosanoic acid
InChIKey: HRAQSWKGRRUBDJ-OMUAVVNCSA-N
SMILES: O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)[C@@H](C3C4=CC=CC=C4CCC5=CC=CC=C35)NC(C)=O
Biological Activity: PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].
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PD 145065 | PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells. | |||||||||||||||||||||
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Keywords
