1557268-90-2
Chemical Structure
Avitinib dihydrochloride
Synonym(s): Abivertinib dihydrochloride; AC0010 dihydrochloride
- CAS No.: 1557268-90-2
- Formula:C26H28Cl2FN7O2
- Molecular Weight:560.45
InChIKey: NFPCFFZEIWPSBM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(OC2=NC(NC3=CC=C(N4CCN(CC4)C)C(F)=C3)=NC5=C2C=CN5)=CC=C1)C=C.Cl.Cl
Biological Activity: Avitinib (Abivertinib) dihydrochloride is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib dihydrochloride is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib dihydrochloride shows anticancer effects[1][2].
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Avitinib dihydrochloride | Avitinib (Abivertinib) dihydrochloride is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib dihydrochloride is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib dihydrochloride shows anticancer effects. | |||||||||||||||||||||
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- [1]. Xu X, Mao L, Xu W, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016;15(11):2586-2597. [Content Brief]
- [2]. Yan X, Zhou Y, Huang S, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706. [Content Brief]
Keywords
