157327-97-4
Chemical Structure
2’-dG (iBu)-2’-phosphoramidite
- CAS No.: 157327-97-4
- Formula:C45H55N6O8P
- Molecular Weight:838.93
IUPAC Name: (2R,3R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) (2,4-dimethylpentan-3-yl)phosphonite
InChIKey: CECINRDKJHVVOZ-MSRFBNOYSA-N
SMILES: O=C1NC(NC(C(C)C)=O)=NC2=C1N=CN2[C@@H]3O[C@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C[C@H]3OP(OCCC#N)C(C(C)C)C(C)C
Biological Activity: 2’-dG (iBu)-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
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2’-dG (iBu)-2’-phosphoramidite | 2’-dG (iBu)-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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Keywords
