157564-11-9
Chemical Structure
Nepaprazole sodium
Synonym(s): rel-TY-11345
- CAS No.: 157564-11-9
- Formula:C18H19N3NaO2S
- Molecular Weight:364.42
IUPAC Name: (9R)-9-((1H-benzo[d]imidazol-2-yl)sulfinyl)-4-methoxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine, sodium salt
InChIKey: PWGFYXJHFWTGJX-YOKRHOHMSA-N
SMILES: S(=O)([C@]1(C=2C(=C(OC)C=CN2)CCCC1)[H])C=3NC=4C(N3)=CC=CC4.[Na]
Biological Activity: Nepaprazole sodium (rel-TY-11345) is a proton pump H+/K+-ATPase inhibitor. Nepaprazole sodium inhibits H+/K+-ATPase activity in rabbit gastric mucosal microsomes, with IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively, and its inhibitory activity is enhanced under weakly acidic conditions. Nepaprazole sodium inhibits basal and Tetragastrin (HY-125556)-stimulated gastric acid secretion. Nepaprazole sodium can be used in studies on gastric proton pump function, gastric acid secretion, and mechanisms related to peptic ulcers[1][2].
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Nepaprazole sodium | Nepaprazole sodium (rel-TY-11345) is a proton pump H+/K+-ATPase inhibitor. Nepaprazole sodium inhibits H+/K+-ATPase activity in rabbit gastric mucosal microsomes, with IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively, and its inhibitory activity is enhanced under weakly acidic conditions. Nepaprazole sodium inhibits basal and Tetragastrin (HY-125556)-stimulated gastric acid secretion. Nepaprazole sodium can be used in studies on gastric proton pump function, gastric acid secretion, and mechanisms related to peptic ulcers. | |||||||||||||||||||||
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References
- [1]. Yamaguchi T, et al. Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals. Japanese journal of pharmacology. 1993 Aug;62(4):363-71. [Content Brief]
- [2]. Yamada S, et al. Synthesis of Stable Solvates of Monosodium 2-[(R*S,9S*)-(4-Methoxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole. Yakugaku Zasshi. 1996;116(8):657-670.
