159659-05-9
Chemical Structure
Z-Gly-Pro-Phe-Leu-CHO
Synonym(s): Z-GPFL-CHO
- CAS No.: 159659-05-9
- Formula:C30H38N4O6
- Molecular Weight:550.65
InChIKey: UHOXMCLZGLAXAZ-GSDHBNRESA-N
SMILES: O=C([C@H](CCC1)N1C(CNC(OCC2=CC=CC=C2)=O)=O)N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC3=CC=CC=C3
Biological Activity: Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].
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Z-Gly-Pro-Phe-Leu-CHO | Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). | |||||||||||||||||||||
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Keywords
