1613225-53-8
Chemical Structure
Teixobactin
- CAS No.: 1613225-53-8
- Formula:C58H95N15O15
- Molecular Weight:1242.47
IUPAC Name: (R)-N1-((2R,3S)-1-(((2S,3S)-1-(((S)-1-(((3S,6S,9S,12R,13S)-6-(((S)-2-amino-4,5-dihydro-1H-imidazol-5-yl)methyl)-3-((S)-sec-butyl)-9,13-dimethyl-2,5,8,11-tetraoxo-1-oxa-4,7,10-triazacyclotridecan-12-yl)amino)-3-hydroxy-1-oxopropan-2-yl)amino)-3-methyl-1-ox
InChIKey: LMBFAGIMSUYTBN-MPZNNTNKSA-N
SMILES: O=C(N[C@@](C(O[C@H]([C@H](C(N[C@H](C(N1)=O)C)=O)NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@@H]([C@@H](C)CC)NC([C@@H](CCC(N)=O)NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@H](NC)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)[C@@H]1C[C@H]3CN=C(N3)N
Biological Activity: Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3].
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Teixobactin | Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III. | |||||||||||||||||||||
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- [1]. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. [Content Brief]
- [2]. Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. [Content Brief]
- [3]. Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. [Content Brief]
Keywords
