1616344-00-3
Chemical Structure
5-Octyl-α-ketoglutarate
Synonym(s): 5-Octyl 2-oxopentanedioate
- CAS No.: 1616344-00-3
- Formula:C13H22O5
- Molecular Weight:258.31
IUPAC Name: 5-(octyloxy)-2,5-dioxopentanoic acid
InChIKey: SZEOIQZPNSBRJC-UHFFFAOYSA-N
SMILES: O=C(C(CCC(OCCCCCCCC)=O)=O)O
Biological Activity: 5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1].
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5-Octyl-α-ketoglutarate | 5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation. | |||||||||||||||||||||
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Keywords
