161856-02-6
Chemical Structure
OCA 983
- CAS No.: 161856-02-6
- Formula:C20H31N3O6S
- Molecular Weight:441.54
IUPAC Name: (4R,5S,6S)-3-(((2R,3R)-2-(((S)-2-amino-3-methylbutanamido)methyl)tetrahydrofuran-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
InChIKey: AFIMUUSGRZSMCR-LPZKKVOTSA-N
SMILES: OC(C1=C(S[C@H]2[C@H](OCC2)CNC([C@@H](N)C(C)C)=O)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O)=O
Biological Activity: OCA 983 is an orally active tetrahydrofuranyl 1β-methylcarbapenem antibiotic. OCA 983 exhibits potent inhibitory activity against class A and class C β-lactamases. OCA 983 possesses a broad antibacterial spectrum, and can be used in the research of infectious diseases[1][2][3].
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OCA 983 | OCA 983 is an orally active tetrahydrofuranyl 1β-methylcarbapenem antibiotic. OCA 983 exhibits potent inhibitory activity against class A and class C β-lactamases. OCA 983 possesses a broad antibacterial spectrum, and can be used in the research of infectious diseases. | |||||||||||||||||||||
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- [1]. Jiraskova N. THF carbapenems. Wyeth Ayerst. Curr Opin Investig Drugs. 2001 Aug;2(8):1035-8. [Content Brief]
- [2]. Bitha P, et al. Convergent syntheses of oral THF 1beta-methylcarbapenems. J Antibiot (Tokyo). 1999 Jul;52(7):643-8. [Content Brief]
- [3]. Bronson JJ, et al. Quinolone, everninomycin, glycylcycline, carbapenem, lipopeptide and cephem antibacterials in clinical development. Curr Med Chem. 2001 Dec;8(14):1775-93. [Content Brief]
Keywords
