1631170-16-5
![N-[[P(S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-184783.gif "N-[[P(S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester Chemical Structure")
Chemical Structure
N-[[P(S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester
- CAS 番号: 1631170-16-5
- Formula:C22H30N3O10P
- Molecular Weight:527.47
IUPAC Name: isopropyl ((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
InChIKey: WAKQLZVLNOKKHE-IAAJYNJHSA-N
SMILES: C[C@]1(O)[C@@H](O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OC(C)C)=O)C)=O)[C@H]1O)N3C(=O)NC(=O)C=C3
Biological Activity: N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester is a 5'(S)-C-methyl phosphoramidate prodrug of 2',5'-C-dimethyluridine, as well as a HCV inhibitor. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester induces anti-HCV activity in HCV genotype 1b replicons with extremely low cytotoxicity. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester can be used in studies related to HCV infection[1].
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N-[[P(S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester | N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester is a 5'(S)-C-methyl phosphoramidate prodrug of 2',5'-C-dimethyluridine, as well as a HCV inhibitor. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester induces anti-HCV activity in HCV genotype 1b replicons with extremely low cytotoxicity. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester can be used in studies related to HCV infection. | |||||||||||||||||||||
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HCV-IN-49 | HCV-IN-49, a phosphoramidate ester derivative, is a HCV protease inhibitor. | |||||||||||||||||||||
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