1643852-84-9
1643852-84-9
Chemical Structure
AGI-16903
- CAS No.: 1643852-84-9
- Formula:C15H9F6N7
- Molecular Weight:401.28
IUPAC Name: 6-(6-(trifluoromethyl)pyridin-2-yl)-N2-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazine-2,4-diamine
InChIKey: PBSZKXPXOCSCCC-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=NC(=CC=C1)C=2N=C(N=C(N2)NC=3C=CN=C(C3)C(F)(F)F)N
Biological Activity: AGI-16903 is a metabolite of Enasidenib (HY-18690). Enasidenib is an orally available, reversible, and selective inhibitor of mutant IDH2 enzymes, with IC50 values of 100 nM and 400 nM against IDH2R140Q and IDH2R172K, respectively[1][2].
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AGI-16903 | AGI-16903 is a metabolite of Enasidenib (HY-18690). Enasidenib is an orally available, reversible, and selective inhibitor of mutant IDH2 enzymes, with IC50 values of 100 nM and 400 nM against IDH2R140Q and IDH2R172K, respectively. | |||||||||||||||||||||
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References
- [1]. Jeremy Travins, et al. N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer. WO2015006592A1. 2016-01-11
- [2]. Dittakavi S, et al. Validated LC-MS/MS Method for Simultaneous Quantitation of Enasidenib and its Active Metabolite, AGI-16903 in Small Volume Mice Plasma: Application to a Pharmacokinetic Study. Drug Res (Stuttg). 2020;70(1):41-48. [Content Brief]
Keywords
