1648707-58-7
Chemical Structure
UNC-2170
- CAS No.: 1648707-58-7
- Formula:C14H21BrN2O
- Molecular Weight:313.23
IUPAC Name: 3-bromo-N-(3-(tert-butylamino)propyl)benzamide
InChIKey: XUFUVCIZFNREBI-UHFFFAOYSA-N
SMILES: O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1
Biological Activity: UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].
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UNC-2170 | 98.84% | UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB). | ||||||||||||||||||||
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Keywords
