1691240-78-4
Chemical Structure
Nafithromycin
Synonym(s): WCK 4873
- CAS No.: 1691240-78-4
- Formula:C42H62N6O11S
- Molecular Weight:859.04
InChIKey: RLFCSBSRGRJFRO-QAOQTAGDSA-N
SMILES: C[C@@]12[C@]([C@H](C([C@@H](C[C@](C)([C@@H]([C@H](C([C@H](C(O[C@@H]2CC)=O)C)=O)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)OC)C)=O)C)([H])[C@@H](C(O1)=O)/C(N)=N/O[C@H](C4=NN=C(C5=CC=CC=N5)S4)C
Biological Activity: Nafithromycin (WCK 4873) is an orally active ketolide antibiotic with activity against Gram-positive bacteria, Gram-negative bacteria, and atypical respiratory pathogens (including drug-resistant strains). Nafithromycin binds to domains II and V of bacterial 23S rRNA and the peptidyl transferase center of the 50S ribosomal subunit, thereby inhibiting protein synthesis. Nafithromycin can be used in research related to bacterial infections[1][2][3][4].
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Nafithromycin | Nafithromycin (WCK 4873) is an orally active ketolide antibiotic with activity against Gram-positive bacteria, Gram-negative bacteria, and atypical respiratory pathogens (including drug-resistant strains). Nafithromycin binds to domains II and V of bacterial 23S rRNA and the peptidyl transferase center of the 50S ribosomal subunit, thereby inhibiting protein synthesis. Nafithromycin can be used in research related to bacterial infections. | |||||||||||||||||||||
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- [1]. Kohlhoff S. In Vitro Activity of Nafithromycin (WCK 4873) against Chlamydia pneumoniae. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0058521.
- [2]. Bhavsar S, et al. WCK 4873 (INN: Nafithromycin): Structure–activity relationship (SAR) identifying a novel lactone ketolide with activity against Streptococcus pneumoniae (SPN) and Streptococcus pyogenes (SPY). Results in Chemistry. 2023;5:100757.
- [3]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
- [4]. Kumar D, et al. Nafithromycin: a potential ketolide antibiotic for combating antimicrobial resistance in community-acquired bacterial pneumonia. Next Research. 2025;2(3):100592.
Keywords
