1799574-70-1
Chemical Structure
CC-90005
- CAS No.: 1799574-70-1
- Formula:C21H27F2N7O2
- Molecular Weight:447.48
IUPAC Name: 2-(((4-(2,2-difluoropropoxy)pyrimidin-5-yl)methyl)amino)-4-(((1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl)amino)pyrimidine-5-carbonitrile
InChIKey: FMKGJQHNYMWDFJ-CVEARBPZSA-N
SMILES: N#CC1=CN=C(NCC2=CN=CN=C2OCC(F)(F)C)N=C1N[C@H]3CC(C)(C)[C@@H](O)CC3
Biological Activity: CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CC-90005 | 99.11% | CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression. | ||||||||||||||||||||
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Keywords
