181238-67-5
181238-67-5
Chemical Structure
MCC-134
- CAS No.: 181238-67-5
- Formula:C16H17N3OS
- Molecular Weight:299.39
IUPAC Name: 1-(4-(1H-imidazol-1-yl)benzoyl)-N-methylcyclobutane-1-carbothioamide
InChIKey: TUMUOLDYJYUKOV-UHFFFAOYSA-N
SMILES: S=C(NC)C1(CCC1)C(C2=CC=C(C=C2)N3C=CN=C3)=O
Biological Activity:
MCC-134, a blocker of mitochondrial and opener of surface ATP-sensitive K+ (KATP) channels, abrogates cardioprotective effects of chronic hypoxia. MCC-134 is a vasorelaxing agent[1][2].
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MCC-134 | MCC-134, a blocker of mitochondrial and opener of surface ATP-sensitive K+ (KATP) channels, abrogates cardioprotective effects of chronic hypoxia. MCC-134 is a vasorelaxing agent. |
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References
- [1]. F Kolár, et al. MCC-134, a blocker of mitochondrial and opener of sarcolemmal ATP-sensitive K+ channels, abrogates cardioprotective effects of chronic hypoxia. Physiol Res. 2005;54(4):467-71. [Content Brief]
- [2]. Norihito Sasaki, et al. MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation. 2003 Mar 4;107(8):1183-8. [Content Brief]
Keywords
