1859081-58-5
1859081-58-5
Chemical Structure
PF-06767832
- CAS No.: 1859081-58-5
- Formula:C22H23N3O3S
- Molecular Weight:409.50
IUPAC Name: N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-4-(4-(thiazol-4-yl)benzyl)picolinamide
InChIKey: VVZZHFMLRHJXTO-RXVVDRJESA-N
SMILES: O[C@@H](COCC1)[C@H]1NC(C2=CC(CC3=CC=C(C4=CSC=N4)C=C3)=C(C)C=N2)=O
Biological Activity: PF-06767832 is a potent muscarinic M1 selective positive allosteric modulator (PAM), with the EC50 of 60 nM. PF-06767832 has good brain penetration[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PF-06767832 | 98.53% | PF-06767832 is a potent muscarinic M1 selective positive allosteric modulator (PAM), with the EC50 of 60 nM. PF-06767832 has good brain penetration. | ||||||||||||||||||||
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References
- [1]. Jennifer E Davoren, et al. Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects. J Med Chem. 2016 Jul 14;59(13):6313-28. [Content Brief]
Keywords
