192231-16-6
Chemical Structure
Altinicline maleate
Synonym(s): SIB-1508Y
- CAS No.: 192231-16-6
- Formula:C16H18N2O4
- Molecular Weight:302.33
IUPAC Name: (S)-3-ethynyl-5-(1-methylpyrrolidin-2-yl)pyridine maleate
InChIKey: BCPPKHPWLRPWBJ-OURKGEEVSA-N
SMILES: CN1[C@H](C2=CN=CC(C#C)=C2)CCC1.OC(/C=C\C(O)=O)=O
Biological Activity: Altinicline (maleate) is an orally active and selective nAChR agonist. Altinicline (maleate) has the potential to study parkinsonism[1][2]. Altinicline (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Altinicline maleate | Altinicline (maleate) is an orally active and selective nAChR agonist. Altinicline (maleate) has the potential to study parkinsonism. Altinicline (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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- [1]. Cosford ND, et al. (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1996 Aug 16;39(17):3235-7. [Content Brief]
- [2]. Schneider JS, et al. Effects of SIB-1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys. Mov Disord. 1998 Jul;13(4):637-42. [Content Brief]
Keywords
