1949837-13-1
Chemical Structure
PROTAC BRD4 Degrader-18
- CAS No.: 1949837-13-1
- Formula:C49H60ClN9O7S2
- Molecular Weight:986.64
IUPAC Name: (2R,4S)-1-((S)-2-(tert-butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: PQOGZKGXGLHDGS-OAKHUPCYSA-N
SMILES: CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C[C@@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)C7=NN=C(C)N27
Biological Activity: PROTAC BRD4 Degrader-18 is a PROTAC BRD4 degrader. PROTAC BRD4 Degrader-18 binds to BRD4 and recruits E3 ubiquitin ligase, inducing ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-18 exhibits antiproliferative activity against ovarian cancer cell lines. PROTAC BRD4 Degrader-18 can be used in research related to ovarian cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC BRD4 Degrader-18 | PROTAC BRD4 Degrader-18 is a PROTAC BRD4 degrader. PROTAC BRD4 Degrader-18 binds to BRD4 and recruits E3 ubiquitin ligase, inducing ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-18 exhibits antiproliferative activity against ovarian cancer cell lines. PROTAC BRD4 Degrader-18 can be used in research related to ovarian cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
