1974336-09-8
1974336-09-8
Chemical Structure
AB8939
- CAS No.: 1974336-09-8
- Formula:C22H24N4O3
- Molecular Weight:392.45
SMILES: O=C1NCCN1C2=CC=C(C3=CN=C(NC4=CC(COCC)=CC=C4C)O3)C=C2
Biological Activity: AB8939 is an effective small moleculeMicrotubule/Tubulin polymerization inhibitor with anti-tumor activity (it inhibits tumor cell proliferation with an IC50 of less than 10 nM). AB8939 can effectively evade resistance mechanisms mediated by things like P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis in cells[1].
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AB8939 | AB8939 is an effective small moleculeMicrotubule/Tubulin polymerization inhibitor with anti-tumor activity (it inhibits tumor cell proliferation with an IC50 of less than 10 nM). AB8939 can effectively evade resistance mechanisms mediated by things like P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis in cells. | |||||||||||||||||||||
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References
Keywords
