2068022-09-1
Chemical Structure
Dihydrodiol-Ibrutinib-d5
Synonym(s): PCI-45227-d5
- CAS No.: 2068022-09-1
- Formula:C25H21D5N6O4
- Molecular Weight:479.54
IUPAC Name: 1-((R)-3-(4-amino-3-(4-(phenoxy-d5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one
InChIKey: NWKPMPRXJGMTKQ-ROSSWGEHSA-N
SMILES: NC1=C2C(N([C@@]3([H])CN(CCC3)C(C(O)CO)=O)N=C2C4=CC=C(C=C4)OC5=C([2H])C([2H])=C([2H])C([2H])=C5[2H])=NC=N1
Biological Activity: Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib[1].
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Dihydrodiol-Ibrutinib-d5 | Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib. | |||||||||||||||||||||
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BTK-IN-3 | BTK-IN-3 (example 1) is an inhibitor of BTK. BTK-IN-3 can used to study cancer. | |||||||||||||||||||||
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Keywords
