208706-12-1
208706-12-1
Chemical Structure
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
- CAS No.: 208706-12-1
- Formula:C33H41N5O2
- Molecular Weight:539.71
IUPAC Name: N-((2R)-1-(((3-(aminomethyl)cyclohexyl)methyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)spiro[indene-1,4'-piperidine]-1'-carboxamide
InChIKey: DAMXHAMKVXERLM-DPHZAUTASA-N
SMILES: O=C(N1CCC2(CC1)C=CC3=C2C=CC=C3)N[C@H](CC4=CNC5=C4C=CC=C5)C(NCC6CC(CN)CCC6)=O
Biological Activity: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation[1][2].
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(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 | 95.07% | (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation. | ||||||||||||||||||||
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References
- [1]. Yang L, et al. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9. [Content Brief]
- [2]. Weir K, et al. A potential role for somatostatin signaling in regulating retinal neurogenesis. Sci Rep. 2021 May 26;11(1):10962. doi: 10.1038/s41598-021-90554-3. Erratum in: Sci Rep. 2021 Aug 16;11(1):16948. [Content Brief]
Keywords
