2095417-25-5
Chemical Structure
6-Methylpurine-β-D-(3-azido-3-deoxy)riboside
- CAS No.: 2095417-25-5
- Formula:C11H13N7O3
- Molecular Weight:291.27
IUPAC Name: (2R,3R,4S,5S)-4-azido-5-(hydroxymethyl)-2-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3-ol
InChIKey: HPBJRUZZQUZFRC-PNHWDRBUSA-N
SMILES: OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N2C(N=CN=C3C)=C3N=C2)O1
Biological Activity: 6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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6-Methylpurine-β-D-(3-azido-3-deoxy)riboside | 6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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