2095417-35-7
Chemical Structure
2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside
- CAS No.: 2095417-35-7
- Formula:C13H14ClN5O4
- Molecular Weight:339.73
IUPAC Name: (2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-(hydroxymethyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-ol
InChIKey: QAXQMTXPZDSDLF-WOUKDFQISA-N
SMILES: O[C@H]1[C@@H](OCC#C)[C@H](N(C=N2)C3=C2C(Cl)=NC(N)=N3)O[C@@H]1CO
Biological Activity: 2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside | 2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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