2101321-90-6
Chemical Structure
CNBDA
- CAS No.: 2101321-90-6
- Formula:C30H40O7
- Molecular Weight:512.64
IUPAC Name: 4,4'-(4'-carboxy-4-(nonyloxy)-[1,1'-biphenyl]-3,5-diyl)dibutyric acid
InChIKey: GLVGBEAYRNBVMW-UHFFFAOYSA-N
SMILES: O=C(O)C=1C=CC(=CC1)C2=CC(=C(OCCCCCCCCC)C(=C2)CCCC(=O)O)CCCC(=O)O
Biological Activity: CNBDA is a selective SHP2 inhibitor with an IC50 of 5 μM. CNBDA binds to the active site of SHP2 through interactions with surrounding positively charged and polar amino acids, inhibits the PTPase activity of SHP2, and blocks the autodephosphorylation of SHP2. CNBDA inhibits the transformed phenotype, proliferation, anchorage-independent growth, and mammosphere formation of breast cancer cells, as well as EGF-induced Ras-ERK and PI3K-Akt signaling pathways, downregulates HER2 expression, and induces cell death. CNBDA can be used in breast cancer-related research[1].
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CNBDA | CNBDA is a selective SHP2 inhibitor with an IC50 of 5 μM. CNBDA binds to the active site of SHP2 through interactions with surrounding positively charged and polar amino acids, inhibits the PTPase activity of SHP2, and blocks the autodephosphorylation of SHP2. CNBDA inhibits the transformed phenotype, proliferation, anchorage-independent growth, and mammosphere formation of breast cancer cells, as well as EGF-induced Ras-ERK and PI3K-Akt signaling pathways, downregulates HER2 expression, and induces cell death. CNBDA can be used in breast cancer-related research. | |||||||||||||||||||||
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Keywords
