2115022-67-6
2115022-67-6
Chemical Structure
PF-06827443
- CAS No.: 2115022-67-6
- Formula:C24H24N2O4
- Molecular Weight:404.46
IUPAC Name: 2-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-6-(4-(oxazol-4-yl)benzyl)isoindolin-1-one
InChIKey: RBMHKFVYRIRMOG-GOTSBHOMSA-N
SMILES: O=C1C2=CC(CC3=CC=C(C4=COC=N4)C=C3)=C(C)C=C2CN1[C@@H]5[C@H](COCC5)O
Biological Activity: PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion[1].
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PF-06827443 | PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion. | |||||||||||||||||||||
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References
Keywords
