2162116-09-6
Chemical Structure
BS148
- CAS No.: 2162116-09-6
- Formula:C21H31NS2
- Molecular Weight:361.61
IUPAC Name: 1-((1,4-dithiaspiro[4.5]decan-2-yl)methyl)-4-benzylpiperidine
InChIKey: NFYUFTSYYMYPCG-UHFFFAOYSA-N
SMILES: N1(CC2SC3(CCCCC3)SC2)CCC(CC4=CC=CC=C4)CC1
Biological Activity: BS148 is a selective sigma-2 receptor (S2R) agonist with a Ki 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP). BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma[1][2].
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BS148 | BS148 is a selective sigma-2 receptor (S2R) agonist with a Ki 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP). BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma. | |||||||||||||||||||||
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- [1]. Claudia Sorbi, et al. BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting. Int J Mol Sci. 2023 Jun 2;24(11):9684. [Content Brief]
- [2]. Franchini S, et al. Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma. ChemMedChem. 2017 Nov 22;12(22):1893-1905. [Content Brief]
Keywords
