216976-76-0
Chemical Structure
3’-Azido-3’-deoxy-beta-L-adenosine
- CAS No.: 216976-76-0
- Formula:C10H12N8O3
- Molecular Weight:292.25
IUPAC Name: (2S,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-azido-5-(hydroxymethyl)tetrahydrofuran-3-ol
InChIKey: HTWSTKVLFZRAPM-CIXYTLPCSA-N
SMILES: O[C@H]1[C@@H](N=[N+]=[N-])[C@H](CO)O[C@@H]1N2C3=C(C(N)=NC=N3)N=C2
Biological Activity: 3’-Azido-3’-deoxy-beta-L-adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-beta-L-adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3’-Azido-3’-deoxy-beta-L-adenosine | 3’-Azido-3’-deoxy-beta-L-adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-beta-L-adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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