217798-45-3
Chemical Structure
NSD2-PWWP1-IN-5
- CAS No.: 217798-45-3
- Formula:C13H10N2OSe
- Molecular Weight:289.19
InChIKey: OEBCJOYKKPAJTD-UHFFFAOYSA-N
SMILES: O=C(N(C1=CC=C(N)C=C1)[Se]2)C3=C2C=CC=C3
Biological Activity: NSD2-PWWP1-IN-5 (Compound 13) is an effective NSD2-PWWP1 inhibitor with a Kd value of 78 nM. NSD2-PWWP1-IN-5 competitively blocks the recognition of H3K36me2 and DNA by NSD2-PWWP1, thereby weakening its binding ability to nucleosomes. NSD2-PWWP1-IN-5 inhibits the proliferation of U2OS osteosarcoma cells and induces cell cycle arrest and apoptosis. NSD2-PWWP1-IN-5 can be used for the study of osteosarcoma[1].
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NSD2-PWWP1-IN-5 | NSD2-PWWP1-IN-5 (Compound 13) is an effective NSD2-PWWP1 inhibitor with a Kd value of 78 nM. NSD2-PWWP1-IN-5 competitively blocks the recognition of H3K36me2 and DNA by NSD2-PWWP1, thereby weakening its binding ability to nucleosomes. NSD2-PWWP1-IN-5 inhibits the proliferation of U2OS osteosarcoma cells and induces cell cycle arrest and apoptosis. NSD2-PWWP1-IN-5 can be used for the study of osteosarcoma. | |||||||||||||||||||||
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Keywords
