2193367-28-9
Chemical Structure
EN1033
- CAS No.: 2193367-28-9
- Formula:C15H18N2O
- Molecular Weight:242.32
IUPAC Name: 1-(2,3,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(5H)-yl)prop-2-en-1-one
InChIKey: FXMWAKUAPVWWLR-UHFFFAOYSA-N
SMILES: C=CC(N1C2=CC=CC=C2CN3C(CCC3)C1)=O
Biological Activity: EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders[1].
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EN1033 | 99.96% | EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders. | ||||||||||||||||||||
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Keywords
