219691-94-8
219691-94-8
Chemical Structure
KB-141
- CAS No.: 219691-94-8
- Formula:C17H16Cl2O4
- Molecular Weight:355.21
IUPAC Name: 2-(3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl)acetic acid
InChIKey: OZYQIQVPUZANTM-UHFFFAOYSA-N
SMILES: O=C(CC1=CC(Cl)=C(C(Cl)=C1)OC2=CC=C(C(C(C)C)=C2)O)O
Biological Activity: KB-141 is a potent and selective TRβ agonist. The IC50 values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo[1][2].
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KB-141 | KB-141 is a potent and selective TRβ agonist. The IC50 values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo. | |||||||||||||||||||||
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Keywords
