2202782-90-7
Chemical Structure
Amidate-VC-PAB-MMAF
- CAS No.: 2202782-90-7
- Formula:C69H102N11O16P
- Molecular Weight:1372.59
IUPAC Name: ((2R,3R)-3-((2S)-1-((3R,4S,5S)-4-((2S)-2-((2S)-2-((((4-((2S)-2-((2S)-2-(4-((ethoxy(ethynyl)phosphoryl)amino)benzamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl)oxy)carbonyl)(methyl)amino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methy
InChIKey: RREPXHUNYRMOKF-SHXVKUNHSA-N
SMILES: C[C@@H](C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(C(C=C4)=CC=C4N[P](OCC)(C#C)=O)=O)=O)=O)=O)=O)=O)=O)OC
Biological Activity: Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs[1].
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Amidate-VC-PAB-MMAF | Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs. | |||||||||||||||||||||
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Keywords
