221164-28-9
Chemical Structure
KRP-199
- CAS No.: 221164-28-9
- Formula:C22H14F3N5O7
- Molecular Weight:517.37
IUPAC Name: 7-(4-((((4-carboxyphenyl)carbamoyl)oxy)methyl)-1H-imidazol-1-yl)-3-oxo-6-(trifluoromethyl)-3,4-dihydroquinoxaline-2-carboxylic acid
InChIKey: AEFZZVQZPBFFPN-UHFFFAOYSA-N
SMILES: O=C(C1=NC2=C(C=C(C(F)(F)F)C(N3C=C(COC(NC4=CC=C(C(O)=O)C=C4)=O)N=C3)=C2)NC1=O)O
Biological Activity: KRP-199 (compound 14h) is an α-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPA-R) antagonist (Ki=16 nM) with high potency and selectivity for AMPA-R in vitro and good neuroprotective effects in vivo. KRP-199 can be used in the study of neurodegenerative diseases[1].
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KRP-199 | KRP-199 (compound 14h) is an α-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPA-R) antagonist (Ki=16 nM) with high potency and selectivity for AMPA-R in vitro and good neuroprotective effects in vivo. KRP-199 can be used in the study of neurodegenerative diseases. | |||||||||||||||||||||
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Keywords
