2213468-04-1
Chemical Structure
PF-06807656
- CAS No.: 2213468-04-1
- Formula:C19H20ClN5O4S
- Molecular Weight:449.91
IUPAC Name: 3-(N-(4-chlorophenyl)sulfamoyl)-4-methoxy-N-(1-(2-methyl-2H-1,2,3-triazol-4-yl)ethyl)benzamide
InChIKey: DERVNKULTWJINM-UHFFFAOYSA-N
SMILES: O=C(NC(C1=NN(C)N=C1)C)C2=CC=C(OC)C(S(=O)(NC3=CC=C(Cl)C=C3)=O)=C2
Biological Activity: PF-06807656 is a selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor. PF-06807656 has an IC50 of 61 nM against hROMK in patch-clamp assays. PF-06807656 exhibits high selectivity for inhibiting rat ROMK and is insensitive to N171D pore mutations. PF-06807656 may be used in cardiovascular disease research[1].
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PF-06807656 | PF-06807656 is a selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor. PF-06807656 has an IC50 of 61 nM against hROMK in patch-clamp assays. PF-06807656 exhibits high selectivity for inhibiting rat ROMK and is insensitive to N171D pore mutations. PF-06807656 may be used in cardiovascular disease research. | |||||||||||||||||||||
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Keywords
