2230873-67-1
Chemical Structure
KRAS inhibitor-16
- CAS No.: 2230873-67-1
- Formula:C20H16Cl2FN3O2S
- Molecular Weight:452.33
IUPAC Name: 1-(4-(5-chloro-6-(2-chloro-5-hydroxyphenyl)-7-fluorobenzo[c]isothiazol-3-yl)piperazin-1-yl)prop-2-en-1-one
InChIKey: UPHZHQLQCQSBQD-UHFFFAOYSA-N
SMILES: C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
Biological Activity: KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
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KRAS inhibitor-16 | KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers. | |||||||||||||||||||||
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Keywords
