2240190-29-6
2240190-29-6
Chemical Structure
Meribatinib
- CAS No.: 2240190-29-6
- Formula:C21H17ClF3N5O2
- Molecular Weight:463.84
InChIKey: YPFVDXZDEJXGKH-CQSZACIVSA-N
SMILES: ClC(F)(F)OC(C=C1)=CC=C1NC(C2=CC(C3=NC=CN=C3)=C(N4CC[C@H](C4)F)N=C2)=O
Biological Activity: Meribatinib (compound 17) is a potent allosteric inhibitor of Bcr-Abl kinase. Meribatinib binds to the myristoyl binding pocket of the Bcr-Abl protein, locking the kinase domain in an inactive state. Meribatinib can be used for research on chronic myeloid leukemia[1].
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Meribatinib | Meribatinib (compound 17) is a potent allosteric inhibitor of Bcr-Abl kinase. Meribatinib binds to the myristoyl binding pocket of the Bcr-Abl protein, locking the kinase domain in an inactive state. Meribatinib can be used for research on chronic myeloid leukemia. | |||||||||||||||||||||
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