224054-76-6
Chemical Structure
AMG-126737
- CAS No.: 224054-76-6
- Formula:C33H38N6O6S2
- Molecular Weight:678.82
IUPAC Name: 3,3'-(((((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(azanediyl))bis(sulfonyl))dibenzimidamide
InChIKey: CTLMBCYIAXNYOG-UHFFFAOYSA-N
SMILES: O=S(NCC1=CC=C(OCCCCCOC2=CC=C(CNS(=O)(C3=CC(C(N)=N)=CC=C3)=O)C=C2)C=C1)(C4=CC(C(N)=N)=CC=C4)=O
Biological Activity: AMG-126737 is an orally active and highly selective human mast cell tryptase inhibitor with a Ki of 90 nM. AMG-126737 suppresses early/late-phase bronchoconstriction in sheep models. AMG-126737 is promising for research of asthma and allergic diseases[1].
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AMG-126737 | AMG-126737 is an orally active and highly selective human mast cell tryptase inhibitor with a Ki of 90 nM. AMG-126737 suppresses early/late-phase bronchoconstriction in sheep models. AMG-126737 is promising for research of asthma and allergic diseases. | |||||||||||||||||||||
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Keywords
