2247543-65-1
2247543-65-1
Chemical Structure
WS-383 free base
- CAS No.: 2247543-65-1
- Formula:C18H20ClN9S2
- Molecular Weight:461.99
IUPAC Name: 2-(5-((2-((4-chlorobenzyl)thio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio)-1H-tetrazol-1-yl)-N,N-dimethylethan-1-amine
InChIKey: MGESDQAAIJOGJA-UHFFFAOYSA-N
SMILES: CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23
Biological Activity: WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
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WS-383 free base | WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. | |||||||||||||||||||||
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References
Keywords
