2259318-54-0
Chemical Structure
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
- CAS No.: 2259318-54-0
- Formula:C70H83N9O22
- Molecular Weight:1402.46
IUPAC Name: 4-((S)-2-((S)-2-(4-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl)butanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (2-oxo-2-((2S,4S)-2,5,12-trihydroxy-7-methoxy-4-(((1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyloctahydro-1H-pyrano[4',3':4,5]oxazolo
InChIKey: MQEXMWGXCVPEOU-KYJWDNHDSA-N
SMILES: C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCN(C)C(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC7=CC=C(N8C(C=CC8=O)=O)C=C7)=O)=O)=O)C=C6)=O)=O)=O)(O)C4)C(O)=C9C(C(C%10=C(OC)C=CC=C%10C9=O)=O)=C5O
Biological Activity: Mal-Phe-C4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-Phe-C4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682[1].
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Mal-Phe-C4-VC-PAB-DMEA-PNU-159682 | Mal-Phe-C4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-Phe-C4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. | |||||||||||||||||||||
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Keywords
