227951-89-5
227951-89-5
Chemical Structure
FK-788
- CAS No.: 227951-89-5
- Formula:C26H25NO6
- Molecular Weight:447.48
IUPAC Name: (R)-2-((6-(((diphenylcarbamoyl)oxy)methyl)-6-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)acetic acid
InChIKey: UZJAIYJXBYWENR-AREMUKBSSA-N
SMILES: O=C(O)COC1=C2CC[C@](O)(COC(N(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC2=CC=C1
Biological Activity: FK-788 is a PGI(2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM[1][2].
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FK-788 | FK-788 is a PGI(2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM. | |||||||||||||||||||||
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References
- [1]. Kouji Hattori, et al. Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3091-5. [Content Brief]
- [2]. Fujiko Takamura, et al. Metabolism investigation leading to novel drug design 2: orally active prostacyclin mimetics. Part 5. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4475-8. [Content Brief]
Keywords
