2305355-64-8
2305355-64-8
Chemical Structure
Zilganersen sodium
Synonym(s): ION373 sodium
- CAS No.: 2305355-64-8
- Formula:C230H301N67O127P19S13Na19
- Molecular Weight:7060.8 (free acid)
SMILES: [Zilganersen (sodium)]
Biological Activity: Zilganersen (ION373) sodium is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen sodium reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen sodium can be used for the research of Alexander disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Zilganersen sodium | 91.43% | Zilganersen (ION373) sodium is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen sodium reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen sodium can be used for the research of Alexander disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Jokūbas Leikauskas. Advances in enzymatic manufacturing, therapeutic pipelines, and regulatory pathways for nucleic acid therapeutics. Nucleic Acid Insights 2026; 3(1), 5-10.
- [2]. Alyssa C. Hill, et al. The MOE Modification of RNA: Origins and Widescale Impact on the Oligonucleotide Therapeutics Field. Helv. Chim. Acta 2023, 106, e202200169.
Keywords
