234779-34-1
Chemical Structure
ALE-0540
- CAS No.: 234779-34-1
- Formula:C14H11N3O5
- Molecular Weight:301.25
IUPAC Name: 2-((2-hydroxyethyl)amino)-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
InChIKey: SURCGQGDUADKBL-UHFFFAOYSA-N
SMILES: O=C1N(NCCO)C(C2=CC([N+]([O-])=O)=CC3=CC=CC1=C23)=O
Biological Activity: ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the study of pain[1].
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ALE-0540 | 98.24% | ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the study of pain. | ||||||||||||||||||||
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Keywords
