2351940-23-1
Chemical Structure
ZW-1226
- CAS No.: 2351940-23-1
- Formula:C25H16N4O3
- Molecular Weight:420.42
InChIKey: FGXVXIIWZSHBMQ-UHFFFAOYSA-N
SMILES: O=C(N=C1C2=CC3=C(C=C(C#N)C=C3)N1C4=CC=C(OCC5=CC=CC=C5)C=C4)NC2=O
Biological Activity: ZW-1226 is a dual Tyrosyl DNA phosphodiesterase 2 (TDP2) and Multidrug resistance-associated protein 1 (MRP1) inhibitor with IC50 values of 0.2 and 0.5 μM, respectively. ZW-1226 exhibits selectivity over other ABC transporters. ZW-1226 elevates intracellular GSH levels, and reverses MRP1-mediated drug resistance. ZW-1226 can be used for the research of leukemia, non-small-cell lung cancer, and multidrug resistant small-cell lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZW-1226 | 98.13% | ZW-1226 is a dual Tyrosyl DNA phosphodiesterase 2 (TDP2) and Multidrug resistance-associated protein 1 (MRP1) inhibitor with IC50 values of 0.2 and 0.5 μM, respectively. ZW-1226 exhibits selectivity over other ABC transporters. ZW-1226 elevates intracellular GSH levels, and reverses MRP1-mediated drug resistance. ZW-1226 can be used for the research of leukemia, non-small-cell lung cancer, and multidrug resistant small-cell lung cancer. | ||||||||||||||||||||
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- [1]. Belhadj Z, et al. Cancer sensitizing effect of deazaflavin analogs is associated with increased intracellular drug accumulation. Eur J Pharm Sci. 2024;193:106686. [Content Brief]
- [2]. Belhadj Z, et al. Characterization of a deazaflavin analog as a potent inhibitor of multidrug resistance-associated protein 1. Biomed Pharmacother. 2024;178:117167. [Content Brief]
Keywords
