2375374-15-3
Chemical Structure
Z1609609733
- CAS No.: 2375374-15-3
- Formula:C30H27Cl2N3O6
- Molecular Weight:596.46
IUPAC Name: 1-acetoxyethyl 2-(4-(3-(4,5-dichloro-1-methyl-1H-indole-2-carboxamido)oxetan-3-yl)phenyl)-2-(pyridin-3-yl)acetate
InChIKey: DMTXRTLDBZBPQQ-UHFFFAOYSA-N
SMILES: O=C(OC(OC(C)=O)C)C(C1=CC=C(C2(NC(C(N3C)=CC4=C3C=CC(Cl)=C4Cl)=O)COC2)C=C1)C5=CC=CN=C5
Biological Activity: Z1609609733 (Compound 18) is a non-covalent 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 1.46 μM. Z1609609733 significantly inhibits serine synthesis and cancer metabolism with complete abrogation of cell proliferation[1].
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Z1609609733 | Z1609609733 (Compound 18) is a non-covalent 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 1.46 μM. Z1609609733 significantly inhibits serine synthesis and cancer metabolism with complete abrogation of cell proliferation. | |||||||||||||||||||||
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Keywords
