2408639-81-4
Chemical Structure
Topoisomerase I inhibitor 7
- CAS No.: 2408639-81-4
- Formula:C22H19N3O5
- Molecular Weight:405.40
IUPAC Name: (S)-3-(3-aminopyrrolidine-1-carbonyl)-4,11-dihydroxy-2-methyl-1H-naphtho[2,3-f]indole-5,10-dione
InChIKey: WAQPMWBELPXNNM-JTQLQIEISA-N
SMILES: CC1=C(C2=C(C3=C(C(O)=C2N1)C(C4=C(C3=O)C=CC=C4)=O)O)C(N5CC[C@@H](C5)N)=O
Biological Activity: Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones[1].
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Topoisomerase I inhibitor 7 | Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones. | |||||||||||||||||||||
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